NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.

Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML
Cancer Res. 2003 63 (17): 5636-45

PMID: 14500406

MeSH Terms (14)

Animals Anticarcinogenic Agents Gene Expression Regulation, Enzymologic Glutamate-Cysteine Ligase Humans Indoles Intracellular Signaling Peptides and Proteins Kelch-Like ECH-Associated Protein 1 Mice NADPH Oxidases Proteins Quinuclidines Structure-Activity Relationship Tumor Cells, Cultured

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