Amygdala kindling potentiates seizure-stimulated immediate-early gene expression in rat cerebral cortex.

Duman RS, Craig JS, Winston SM, Deutch AY, Hernandez TD
J Neurochem. 1992 59 (5): 1753-60

PMID: 1402920 · DOI:10.1111/j.1471-4159.1992.tb11007.x

Kindling induces long-term adaptations in neuronal function that lead to a decreased threshold for induction of seizures. In the present study, the influence of amygdala kindling on levels of mRNA for the immediate-early genes (IEGs) c-fos, c-jun, and NGF1-A were examined both before and after an acute electroconvulsive seizure (ECS). Although amygdala kindling did not significantly influence resting levels of c-fos mRNA in cerebral cortex, ECS-stimulated levels of c-fos mRNA (examined 45 min after ECS) were approximately twofold greater in the cerebral cortex of kindled rats relative to sham-treated controls. The influence of kindling on IEG expression was dependent on the time course of kindling, as ECS-stimulated levels of c-fos mRNA were not significantly increased in stage 2 kindled animals. ECS-stimulated levels of c-jun and NGF1-A mRNA were also significantly increased in cerebral cortex of kindled rats relative to sham-treated controls. The influence of kindling on IEG expression was long-lasting because an acute ECS stimulus significantly elevated levels of c-fos and c-jun mRNA in the cerebral cortex of animals that were kindled 5 months previously. In contrast to these effects in cerebral cortex, kindling did not influence ECS-stimulated levels of c-fos mRNA in hippocampus. Finally, immunohistochemical studies revealed lamina-specific changes in the cerebral cortex.(ABSTRACT TRUNCATED AT 250 WORDS)

MeSH Terms (12)

Amygdala Animals Cerebral Cortex Gene Expression Regulation Genes, fos Kindling, Neurologic Male Nerve Growth Factors Rats Rats, Sprague-Dawley RNA, Messenger Seizures

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