Molecular basis of human hypertension: role of angiotensinogen.

Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM
Cell. 1992 71 (1): 169-80

PMID: 1394429 · DOI:10.1016/0092-8674(92)90275-h

Essential hypertension is a common human disease believed to result from the interplay of multiple genetic and environmental determinants. In genetic studies of two large panels of hypertensive sibships from widely separated geographical areas, we obtained evidence of genetic linkage between the angiotensinogen gene (AGT) and hypertension, demonstrated association of AGT molecular variants with the disease, and found significant differences in plasma concentrations of angiotensinogen among hypertensive subjects with different AGT genotypes. The corroboration and replication afforded by these results support the interpretation that molecular variants of AGT constitute inherited predispositions to essential hypertension in humans.

MeSH Terms (15)

Adult Analysis of Variance Angiotensinogen Base Sequence Female Genetic Linkage Humans Hypertension Male Middle Aged Molecular Sequence Data Paris Pedigree Polymorphism, Genetic Utah

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