Autoimmune vasculitis in MRL/Mp-lpr/lpr mice: orthochromatic basophils participate in the development of delayed-type hypersensitivity angiitis.

Moyer CF, Jerome WG, Taylor R, Tulli H, Reinisch CL
Autoimmunity. 1992 12 (3): 159-65

PMID: 1343764 · DOI:10.3109/08916939209148455

The pathogenesis of autoimmune vasculitis is poorly understood. Understanding the immunologic mechanisms governing this disease requires precise identification of the cells which comprise the lesion. In this report, we have evaluated tissue sections from MRL/lpr mice from 16 to 45 weeks of age, representing all stages of clinical vasculitis. We demonstrate that basophil myelocytes participate in the evolution of the delayed-type hypersensitivity (DTH) response which initiates and perpetuates autoimmune vasculitis in these mice. These findings raise questions regarding the immunologic mechanisms by which basophils develop in this lesion and the interaction of basophils. VSMCs and lymphocytes in vasculitic angiodestruction.

MeSH Terms (7)

Animals Autoimmune Diseases Basophils Hypersensitivity, Delayed Lymphoproliferative Disorders Mice Vasculitis

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