p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo.

Reynolds AB, Herbert L, Cleveland JL, Berg ST, Gaut JR
Oncogene. 1992 7 (12): 2439-45

PMID: 1334250

A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding murine p120. The encoded protein lacks significant homology with any reported protein, but it contains four copies of an imperfect 42 amino acid repeat that occurs 12.5 times in the protein encoded by Drosophila armadillo (arm), and its direct homologs, human plakoglobin (plak) and Xenopus laevis beta-catenin (beta-cat). The presence of this motif implies that p120 may share at least one aspect of its function with the arm protein and its homologs.

MeSH Terms (34)

3T3 Cells Amino Acid Sequence Animals Armadillo Domain Proteins Base Sequence beta Catenin Cadherins Cell Adhesion Molecules Cloning, Molecular Cytoskeletal Proteins Desmoplakins DNA DNA Probes Drosophila Drosophila Proteins gamma Catenin Gene Library Humans Insect Hormones Mice Molecular Sequence Data Oncogene Protein pp60(v-src) Phosphoproteins Polymerase Chain Reaction Protein-Tyrosine Kinases Proteins Receptors, Cell Surface Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Substrate Specificity Trans-Activators Transcription Factors Xenopus Xenopus Proteins

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