Effect of firing rate on the calcium permeability in adult neurons during spontaneous action potentials.

Mazzanti M, Galli A, Ferroni A
Biophys J. 1992 63 (4): 926-34

PMID: 1330040 · PMCID: PMC1262230 · DOI:10.1016/S0006-3495(92)81669-7

Calcium channels in neurons mediate a wide variety of essential functions. In addition to contributing to action potential shape, they furnish a substrate that acts as an intracellular second messenger. This study shows that the shape of the neuronal action potential has characteristics that promote long openings of L-type (high threshold) calcium channels. We also present evidence that a change in the firing rate of isolated neurons modulates gating of single calcium channels. This mechanism could be important in modulating neuron excitability and providing a rise in intracellular Ca, when needed.

MeSH Terms (14)

Action Potentials Animals Calcium Calcium Channels Cells, Cultured Electrophysiology Ganglia, Spinal Ion Channel Gating Kinetics Neurons Rats Tetraethylammonium Tetraethylammonium Compounds Time Factors

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