Follow-up evaluation of cervicovaginal human papillomavirus infection in adolescents.

Rosenfeld WD, Rose E, Vermund SH, Schreiber K, Burk RD
J Pediatr. 1992 121 (2): 307-11

PMID: 1322456 · DOI:10.1016/s0022-3476(05)81212-0

We performed a second examination for human papillomavirus (HPV) DNA on 51 sexually experienced 13- to 21-year-old (mean = 17.8 years) female patients seen at an urban teaching hospital. Cervicovaginal lavages were performed 6 to 36 months apart (median = 13.3 months) to collect cells for HPV DNA detection and typing by Southern blot hybridization. At the first and second visits, 39.2% (20/51) and 25.5% (13/51) of patients, respectively, were infected with HPV. Collectively, 56.9% (29/51) of patients had at least one positive HPV test result. Although 7.8% (4/51) were infected with HPV at both visits, only one patient had infection with the same HPV type. These findings suggest that although HPV infection is a common sexually transmitted disease, genotype-specific HPV infection detected by Southern blot at two visits was rare.

MeSH Terms (13)

Adolescent Adult Blotting, Southern Cervix Uteri Female Follow-Up Studies Humans Incidence New York Papillomaviridae Sexual Behavior Tumor Virus Infections Vagina

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