A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.

Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ
J Biol Chem. 2003 278 (46): 45763-9

PMID: 12925531 · DOI:10.1074/jbc.M305481200

MeSH Terms (25)

Animals Anti-Inflammatory Agents, Non-Steroidal Arachidonic Acid Arginine Binding, Competitive Cell Line Crystallography, X-Ray Cyclooxygenase 2 Diclofenac Dose-Response Relationship, Drug Enzyme Inhibitors Insecta Isoenzymes Mice Models, Chemical Models, Molecular Mutagenesis, Site-Directed Mutation Piroxicam Prostaglandin-Endoperoxide Synthases Protein Binding Serine Sulfonamides Time Factors Tyrosine

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