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Growing pains: the cytoskeleton as a critical regulator of pain plasticity.

Bhave G, Gereau RW
Neuron. 2003 39 (4): 577-9

PMID: 12925270 · DOI:10.1016/s0896-6273(03)00500-2

Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic interactions with the cytoskeleton.

MeSH Terms (10)

Animals Cytoskeleton Dinoprostone Epinephrine Neuronal Plasticity Neurons, Afferent Nociceptors Pain Receptors, Chemokine Signal Transduction

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