The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase.

Patel S, Wohlfeil ER, Rademacher DJ, Carrier EJ, Perry LJ, Kundu A, Falck JR, Nithipatikom K, Campbell WB, Hillard CJ
Br J Pharmacol. 2003 139 (5): 1005-13

PMID: 12839875 · PMCID: PMC1573928 · DOI:10.1038/sj.bjp.0705334

MeSH Terms (16)

Amidohydrolases Anesthetics, General Animals Arachidonic Acids Brain Cannabinoid Receptor Modulators Dose-Response Relationship, Drug Endocannabinoids Enzyme Inhibitors Male Mice Mice, Inbred ICR Polyunsaturated Alkamides Propofol Rats Rats, Sprague-Dawley

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