TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase.

Lee DC, Sunnarborg SW, Hinkle CL, Myers TJ, Stevenson MY, Russell WE, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Chang A, Jackson LF
Ann N Y Acad Sci. 2003 995: 22-38

PMID: 12814936 · DOI:10.1111/j.1749-6632.2003.tb03207.x

MeSH Terms (17)

ADAM17 Protein ADAM Proteins Amino Acid Sequence Amphiregulin Animals EGF Family of Proteins Epidermal Growth Factor ErbB Receptors Glycoproteins Heparin-binding EGF-like Growth Factor Intercellular Signaling Peptides and Proteins Ligands Metalloendopeptidases Mice Mice, Knockout Protein Precursors Transforming Growth Factor alpha

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