The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.

Carlomagno T, Blommers MJ, Meiler J, Jahnke W, Schupp T, Petersen F, Schinzer D, Altmann KH, Griesinger C
Angew Chem Int Ed Engl. 2003 42 (22): 2511-5

PMID: 12800173 · DOI:10.1002/anie.200351276

MeSH Terms (11)

Animals Antineoplastic Agents Cattle Epothilones Models, Molecular Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Solutions Structure-Activity Relationship Tubulin

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