Interleukin-4 and interleukin-13 signaling connections maps.

Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD
Science. 2003 300 (5625): 1527-8

PMID: 12791978 · DOI:10.1126/science.1085458

Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy. IL-4 can stimulate two receptors, type I and type II, whereas IL-13 signaling is mediated only by the type II receptor (see the STKE Connections Maps). These cytokines activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. In addition, stimulation of the phosphatidylinositol 3-kinase (PI3K) pathway through recruitment of members of the insulin receptor substrate family may contribute to survival and proliferation.

MeSH Terms (24)

Amino Acid Motifs Animals Asthma Humans Hypersensitivity Interleukin-4 Interleukin-13 Interleukin-13 Receptor alpha1 Subunit Lymphocyte Activation Phosphatidylinositol 3-Kinases Phosphoproteins Phosphorylation Phosphotyrosine Protein-Tyrosine Kinases Protein Structure, Tertiary Receptors, Antigen, T-Cell Receptors, Interleukin Receptors, Interleukin-4 Receptors, Interleukin-13 Signal Transduction src Homology Domains STAT6 Transcription Factor T-Lymphocytes Trans-Activators

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