Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences.

Stanic AK, Park JJ, Joyce S
Immunology. 2003 109 (2): 171-84

PMID: 12757612 · PMCID: PMC1782955 · DOI:10.1046/j.1365-2567.2003.01657.x

This review attempts to illuminate the glycolipid antigen presentation properties of CD1d, how CD1d controls the function of natural T (iNKT) cells and how CD1d and iNKT cells interact to jump-start the immune system. It is postulated that the CD1d-iNKT cell system functions as a sensor, sensing alterations in cellular lipid content by virtue of its affinity for such ligands. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates iNKT cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jump-start the immune system.

MeSH Terms (10)

Antigen Presentation Antigens, CD1 Antigens, CD1d Cell Differentiation Cytokines Humans Immunity, Cellular Killer Cells, Natural Models, Immunological T-Lymphocyte Subsets

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