Uremic malnutrition: new insights into an old problem.

Pupim LB, Ikizler TA
Semin Dial. 2003 16 (3): 224-32

PMID: 12753685 · DOI:10.1046/j.1525-139x.2003.16046.x

Uremic malnutrition is highly prevalent and is associated with poor clinical outcomes in end-stage renal disease (ESRD) patients. Inadequate diet and a state of persistent catabolism play major roles in predisposing these patients to uremic malnutrition and appear to have an additive effect on overall outcome. Recent studies highlight the existence of a complex syndrome involving chronic inflammation, metabolic abnormalities, and hormonal derangements contributing to the increased morbidity and mortality observed in ESRD patients. Novel strategies such as appetite stimulants, anti-inflammatory drugs, and anabolic hormones along with conventional nutritional supplementation may provide potential interventions to improve clinical outcome in ESRD patients.

MeSH Terms (11)

Acidosis Animals Cytokines Humans Inflammation Kidney Failure, Chronic Nutritional Status Nutrition Assessment Nutrition Disorders Parenteral Nutrition Uremia

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