Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

Liu G, Szczepankiewicz BG, Pei Z, Janowick DA, Xin Z, Hajduk PJ, Abad-Zapatero C, Liang H, Hutchins CW, Fesik SW, Ballaron SJ, Stashko MA, Lubben T, Mika AK, Zinker BA, Trevillyan JM, Jirousek MR
J Med Chem. 2003 46 (11): 2093-103

PMID: 12747781 · DOI:10.1021/jm0205696

MeSH Terms (26)

4-Aminobenzoic Acid Administration, Oral Amino Acid Sequence Aminobenzoates Animals Biological Availability Blood Glucose Caco-2 Cells Catalytic Domain Crystallography, X-Ray Enzyme Inhibitors Humans Hypoglycemic Agents Magnetic Resonance Spectroscopy Male Mice Models, Molecular Molecular Sequence Data para-Aminobenzoates Permeability Phenylalanine Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases Rats Stereoisomerism Structure-Activity Relationship

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