Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.

Bianco R, Shin I, Ritter CA, Yakes FM, Basso A, Rosen N, Tsurutani J, Dennis PA, Mills GB, Arteaga CL
Oncogene. 2003 22 (18): 2812-22

PMID: 12743604 · DOI:10.1038/sj.onc.1206388

MeSH Terms (16)

Antineoplastic Agents Apoptosis Carcinoma, Non-Small-Cell Lung Cell Division Enzyme Inhibitors ErbB Receptors Gene Deletion Humans Lung Neoplasms Phosphatidylinositol 3-Kinases Phosphoric Monoester Hydrolases PTEN Phosphohydrolase Recombinant Proteins Transfection Tumor Cells, Cultured Tumor Suppressor Proteins

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