Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice.

Reinmuth N, Liu W, Ahmad SA, Fan F, Stoeltzing O, Parikh AA, Bucana CD, Gallick GE, Nickols MA, Westlin WF, Ellis LM
Cancer Res. 2003 63 (9): 2079-87

PMID: 12727823

MeSH Terms (18)

Angiogenesis Inhibitors Animals Apoptosis Cell Adhesion Cell Division Cell Movement Colonic Neoplasms Disease Models, Animal Endothelium, Vascular Humans Integrin alphaVbeta3 Liver Neoplasms Male Mice Mice, Inbred BALB C Neovascularization, Pathologic Organic Chemicals Signal Transduction

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