Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.

Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG
J Clin Invest. 2003 111 (8): 1201-9

PMID: 12697739 · PMCID: PMC152929 · DOI:10.1172/JCI14172

MeSH Terms (19)

Animals Biopterin Desoxycorticosterone Endothelium, Vascular Hydrogen Peroxide Hypertension Male Mice Mice, Inbred C57BL NADPH Oxidases Nitric Oxide Synthase Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Oxidation-Reduction Rats Rats, Sprague-Dawley Reactive Oxygen Species Superoxides Vasodilation

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