Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.

Szczepankiewicz BG, Liu G, Hajduk PJ, Abad-Zapatero C, Pei Z, Xin Z, Lubben TH, Trevillyan JM, Stashko MA, Ballaron SJ, Liang H, Huang F, Hutchins CW, Fesik SW, Jirousek MR
J Am Chem Soc. 2003 125 (14): 4087-96

PMID: 12670229 · DOI:10.1021/ja0296733

MeSH Terms (16)

Amino Acid Sequence Binding, Competitive Binding Sites Catalysis Drug Design Enzyme Inhibitors Kinetics Ligands Models, Molecular Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular Oxamic Acid Protein Conformation Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases Structure-Activity Relationship

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