How the ubiquitin-proteasome system controls transcription.

Muratani M, Tansey WP
Nat Rev Mol Cell Biol. 2003 4 (3): 192-201

PMID: 12612638 · DOI:10.1038/nrm1049

Gene transcription and ubiquitin-mediated proteolysis are two processes that have seemingly nothing in common: transcription is the first step in the life of any protein and proteolysis the last. Despite the disparate nature of these processes, a growing body of evidence indicates that ubiquitin and the proteasome are intimately involved in gene control. Here, we discuss the deep mechanistic connections between transcription and the ubiquitin-proteasome system, and highlight how the intersection of these processes tightly controls expression of the genetic information.

MeSH Terms (9)

Animals Chromatin DNA-Directed RNA Polymerases Endopeptidases Humans Models, Biological Transcription, Genetic Ubiquitin Ubiquitins

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