Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.

Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES
Neuron. 2003 37 (2): 233-47

PMID: 12546819 · DOI:10.1016/s0896-6273(02)01167-4

The central serotonin (5-HT) neurotransmitter system is an important modulator of diverse physiological processes and behaviors; however, the transcriptional mechanisms controlling its development are largely unknown. The Pet-1 ETS factor is a precise marker of developing and adult 5-HT neurons and is expressed shortly before 5-HT appears in the hindbrain. Here we show that in mice lacking Pet-1, the majority of 5-HT neurons fail to differentiate. Remaining ones show deficient expression of genes required for 5-HT synthesis, uptake, and storage. Significantly, defective development of the 5-HT system is followed by heightened anxiety-like and aggressive behavior in adults. These findings indicate that Pet-1 is a critical determinant of 5-HT neuron identity and implicate a Pet-1-dependent program in serotonergic modulation of behavior.

MeSH Terms (23)

Aggression Alleles Animals Anxiety Behavior, Animal Biogenic Monoamines Carrier Proteins Cell Differentiation Chromatography, High Pressure Liquid Immunohistochemistry In Situ Hybridization Membrane Glycoproteins Membrane Transport Proteins Mice Mice, Knockout Nerve Tissue Proteins Nervous System Neurons Postural Balance Rhombencephalon Serotonin Serotonin Plasma Membrane Transport Proteins Transcription Factors

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