NMR-based modification of matrix metalloproteinase inhibitors with improved bioavailability.

Hajduk PJ, Shuker SB, Nettesheim DG, Craig R, Augeri DJ, Betebenner D, Albert DH, Guo Y, Meadows RP, Xu L, Michaelides M, Davidsen SK, Fesik SW
J Med Chem. 2002 45 (26): 5628-39

PMID: 12477346 · DOI:10.1021/jm020160g

MeSH Terms (13)

Animals Biological Availability Catalytic Domain Hydroxamic Acids Magnetic Resonance Spectroscopy Matrix Metalloproteinase 3 Matrix Metalloproteinase Inhibitors Models, Molecular Naphthalenes Protease Inhibitors Protein Binding Rats Structure-Activity Relationship

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