Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end-stage renal disease.

Caglar K, Hakim RM, Ikizler TA
Nutr Rev. 2002 60 (11): 378-87

PMID: 12462522 · DOI:10.1301/00296640260385928

Uremic malnutrition and chronic inflammation are important comorbid conditions that predict poor clinical outcome in end-stage renal disease (ESRD) patients. These conditions are also closely associated with cardiovascular disease, the major cause of death in ESRD patients. A pathophysiologic link between malnutrition, inflammation, and atherosclerosis has been proposed in this patient population. Indeed, multiple lines of evidence suggest that chronic inflammation can predispose ESRD patients to a catabolic and atherogenic state. Malnutrition can also result from chronic inflammation and can accelerate the progression of cardiovascular disease. Whereas a single common etiology has not been identified in this complex process, nutritional and anti-inflammatory interventions provide potential treatment options to counter the high mortality and morbidity in ESRD patients.

MeSH Terms (10)

Arteriosclerosis Cardiovascular Diseases Diet Humans Inflammation Kidney Failure, Chronic Nutritional Physiological Phenomena Nutrition Disorders Risk Factors Uremia

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