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How do microtubules guide migrating cells?

Small JV, Geiger B, Kaverina I, Bershadsky A
Nat Rev Mol Cell Biol. 2002 3 (12): 957-64

PMID: 12461561 · DOI:10.1038/nrm971

Microtubules have long been implicated in the polarization of migrating cells, but how they carry out this role is unclear. Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility.

MeSH Terms (12)

Actins Animals Cell Adhesion Cell Membrane Structures Cell Movement Cell Polarity Cells, Cultured Cytoskeleton Fibroblasts Green Fluorescent Proteins Luminescent Proteins Microtubules

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