Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Chen JK, Taipale J, Cooper MK, Beachy PA
Genes Dev. 2002 16 (21): 2743-8

PMID: 12414725 · PMCID: PMC187469 · DOI:10.1101/gad.1025302

MeSH Terms (16)

3T3 Cells Animals Antineoplastic Agents Binding Sites Endoplasmic Reticulum Hedgehog Proteins Mice Protein Binding Protein Conformation Receptors, Cell Surface Receptors, G-Protein-Coupled Signal Transduction Smoothened Receptor Teratogens Trans-Activators Veratrum Alkaloids

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