Imaging mass spectrometry: a new tool to investigate the spatial organization of peptides and proteins in mammalian tissue sections.

Chaurand P, Schwartz SA, Caprioli RM
Curr Opin Chem Biol. 2002 6 (5): 676-81

PMID: 12413553

MALDI MS imaging mass spectrometry can be used to map the distribution of targeted compounds in tissue sections with a spatial resolution currently of about 50 microm, providing important molecular information in many areas of biological research. After matrix application, a raster of a section by the laser beam yields ions from compounds in a tissue mass-to-charge range from 1000 to over 100000. Two-dimensional intensity maps can then be reconstructed to provide specific molecular images of a tissue.

MeSH Terms (7)

Animals Humans Image Processing, Computer-Assisted Peptides Proteins Specimen Handling Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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