G protein-coupled receptors in Anopheles gambiae.

Hill CA, Fox AN, Pitts RJ, Kent LB, Tan PL, Chrystal MA, Cravchik A, Collins FH, Robertson HM, Zwiebel LJ
Science. 2002 298 (5591): 176-8

PMID: 12364795 · DOI:10.1126/science.1076196

We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.

MeSH Terms (22)

Alternative Splicing Amino Acid Sequence Animals Anopheles Computational Biology Conserved Sequence Drosophila melanogaster Drosophila Proteins Evolution, Molecular Gene Amplification Gene Expression Genes, Insect Genome GTP-Binding Proteins Insect Proteins Molecular Sequence Data Multigene Family Phylogeny Receptors, Cell Surface Receptors, Odorant Reverse Transcriptase Polymerase Chain Reaction Signal Transduction

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