Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.

Guengerich FP, Miller GP, Hanna IH, Martin MV, L├ęger S, Black C, Chauret N, Silva JM, Trimble LA, Yergey JA, Nicoll-Griffith DA
Biochemistry. 2002 41 (36): 11025-34

PMID: 12206675 · DOI:10.1021/bi020341k

MeSH Terms (17)

Amines Amino Acid Substitution Aspartic Acid Baculoviridae Binding Sites Catalysis Cytochrome P-450 CYP2D6 Humans Hydrogen Bonding Ligands Microsomes, Liver Oxidation-Reduction Recombinant Proteins Spiro Compounds Static Electricity Substrate Specificity Sulfonamides

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