Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis.

Day KC, McCabe MT, Zhao X, Wang Y, Davis JN, Phillips J, Von Geldern M, Ried T, KuKuruga MA, Cunha GR, Hayward SW, Day ML
J Biol Chem. 2002 277 (46): 44475-84

PMID: 12191999 · DOI:10.1074/jbc.M205361200

MeSH Terms (26)

Animals Cell Cycle Cell Differentiation Cell Division Cell Line Culture Media, Serum-Free Cyclin E Epithelial Cells Gene Deletion Genotype Growth Substances Homozygote Immunohistochemistry Karyotyping Kinetics Male Mice Mice, Nude Nucleic Acid Hybridization Phenotype Proliferating Cell Nuclear Antigen Prostate Prostatic Neoplasms Recombination, Genetic Retinoblastoma Protein Time Factors

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