Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant rats.

Meng S, Roberts LJ, Cason GW, Curry TS, Manning RD
Am J Physiol Regul Integr Comp Physiol. 2002 283 (3): R732-8

PMID: 12185008 · DOI:10.1152/ajpregu.00346.2001

The roles of oxidative stress and renal superoxide dismutase (SOD) levels and their association with renal damage were studied in Dahl salt-sensitive (S) and salt-resistant (R)/Rapp strain rats during changes in Na intake. After 3 wk of a high (8%)-Na diet in S rats, renal medullary Cu/Zn SOD was 56% lower and Mn SOD was 81% lower than in R high Na-fed rats. After 1, 2, and 3 wk of high Na, urinary excretion of F(2)-isoprostanes, an index of oxidative stress, was significantly greater in S rats compared with R rats. Plasma F(2)-isoprostane concentration increased in the 2-wk S high Na-fed group. After 3 wk, renal cortical and medullary superoxide production was significantly increased in Dahl S rats on high Na intake, and urinary protein excretion, an index of renal damage, was 273 +/- 32 mg/d in S high Na-fed rats and 35 +/- 4 mg/d in R high Na-fed rats (P < 0.05). In conclusion, salt-sensitive hypertension in the S rat is accompanied by marked decreases in renal medullary SOD and greater renal oxidative stress and renal damage than in R rats.

MeSH Terms (15)

Animals Antioxidants Diet, Sodium-Restricted F2-Isoprostanes Hypertension, Renal Kidney Cortex Kidney Medulla Male Oxidative Stress Proteinuria Rats Rats, Inbred Dahl Reactive Oxygen Species Sodium, Dietary Superoxide Dismutase

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