Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct gamma-OH-1,N( 2)-propano-2'-deoxyguanosine.

Kim HY, Voehler M, Harris TM, Stone MP
J Am Chem Soc. 2002 124 (32): 9324-5

PMID: 12166998 · DOI:10.1021/ja020333r

Spectroscopic evidence is presented for the formation of a carbinolamine interchain cross-link in 5'-CpG-3' sequences, arising from the acrolein adduct gamma-OH-PdG. This may be important in understanding biological processing of acrolein-induced DNA damage in CpG sequences.

MeSH Terms (5)

Acrolein CpG Islands DNA Adducts Nuclear Magnetic Resonance, Biomolecular Purinones

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