Differential lung ventilation after single-lung transplantation for emphysema.

Mitchell JB, Shaw AD, Donald S, Farrimond JG
J Cardiothorac Vasc Anesth. 2002 16 (4): 459-62

PMID: 12154426 · DOI:10.1053/jcan.2002.125142

OBJECTIVE - To review outcome and cardiovascular and respiratory function after initiation of differential lung ventilation for acute severe native lung hyperinflation in patients who have had a single-lung transplant for end-stage emphysema.

DESIGN - Retrospective review.

SETTING - Cardiothoracic tertiary referral center.

PARTICIPANTS - Thirteen patients who had differential lung ventilation for acute severe native lung hyperinflation, of a total of 132 patients who had a single-lung transplant for end-stage emphysema between 1988 and the end of 2000.

INTERVENTIONS - None. measurements and main results: Thirteen patients had differential lung ventilation for acute severe native lung hyperinflation; 7 survived to 1 year after transplant. There was a highly significant (p = 0.0006) improvement in mean PaO(2) from 8.23 (95% confidence interval [CI], 6.15 to 10.3) to 16.6 (95% CI, 12.84 to 20.45) 1 hour after start of differential lung ventilation. The average ratio of estimated dynamic compliance in the native lung compared with the transplanted (donor) lung was 2.69 (95% CI, 1.75 to 3.62).

CONCLUSION - In addition to previous case reports, this series shows that differential lung ventilation is an appropriate treatment for acute severe native lung hyperinflation. A difference in estimated effective dynamic compliance of > or = 2.69 between native and transplanted lung may require differential lung ventilation.

Copyright 2002, Elsevier Science (USA). All rights reserved.

MeSH Terms (12)

Adult Humans Lung Compliance Lung Transplantation Middle Aged Pulmonary Emphysema Retrospective Studies Survival Analysis Tissue Donors Treatment Outcome United Kingdom Ventilators, Mechanical

Connections (1)

This publication is referenced by other Labnodes entities:

Links