Isoform-selective interaction of cyclooxygenase-2 with indomethacin amides studied by real-time fluorescence, inhibition kinetics, and site-directed mutagenesis.

Timofeevski SL, Prusakiewicz JJ, Rouzer CA, Marnett LJ
Biochemistry. 2002 41 (30): 9654-62

PMID: 12135387 · DOI:10.1021/bi0203637

MeSH Terms (14)

Amides Animals Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Indomethacin Isoenzymes Kinetics Mice Mutagenesis, Site-Directed Prostaglandin-Endoperoxide Synthases Sheep Spectrometry, Fluorescence Spectrometry, Mass, Electrospray Ionization

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