The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands.

Cowart LA, Wei S, Hsu MH, Johnson EF, Krishna MU, Falck JR, Capdevila JH
J Biol Chem. 2002 277 (38): 35105-12

PMID: 12124379 · DOI:10.1074/jbc.M201575200

MeSH Terms (17)

Animals Arachidonic Acids Cell Line Cytochrome P-450 CYP4A Cytochrome P-450 Enzyme System Hydroxylation Isoenzymes Ligands Male Mass Spectrometry Microsomes, Liver Mixed Function Oxygenases Protein Binding Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear Transcription Factors

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