Time-dependent involvement of PKA/PKC in contextual memory consolidation.

Wallenstein GV, Vago DR, Walberer AM
Behav Brain Res. 2002 133 (2): 159-64

PMID: 12110449 · DOI:10.1016/s0166-4328(01)00476-4

Rats were implanted bilaterally with cannulae into the dorsal hippocampus and trained in a Pavlovian fear-conditioning paradigm. Four groups of rats were infused intra-cranially with 1-(5'-isoquinolinesulfonyl)-2-methylpiperazine (H7-dihydrochloride), a potent inhibitor of both protein kinase C (PKC) and cAMP-dependent protein kinase (PKA), at different time intervals in order to examine their involvement in the acquisition and consolidation of contextual fear memory. We demonstrate a significant consolidation deficit of long-term contextual fear-conditioning memory that is maximal when PKA and PKC are inhibited at 90 min post-training. These results suggest the existence of a critical time window, during which these enzymes must be activated for the consolidation of long-term memories.

MeSH Terms (13)

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Animals Conditioning, Psychological Cyclic AMP-Dependent Protein Kinases Enzyme Inhibitors Fear Hippocampus Long-Term Potentiation Male Memory Protein Kinase C Rats Rats, Sprague-Dawley

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