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Basal circadian cortisol secretion in women with temporomandibular disorders.

Korszun A, Young EA, Singer K, Carlson NE, Brown MB, Crofford L
J Dent Res. 2002 81 (4): 279-83

PMID: 12097314 · DOI:10.1177/154405910208100411

Muscular temporomandibular disorder (TMD) is a common stress-related condition showing marked comorbidity with depression and fibromyalgia (FM), both of which are associated with dysregulation of cortisol secretion. We measured cortisol levels in 15 women with well-defined TMD and 15 matched controls by sampling blood at 10-minute intervals over 24 hours in a controlled environment. TMD patients showed markedly increased daytime cortisol levels 30% to 50% higher than those of controls (p = 0.0032) and a one-hour phase delay in the timing of maximum cortisol levels (p = 0.048). Increased activation of the stress hormone axis by conscious pain perception is a likely explanation, but the magnitude of the increase could indicate that pain in the facial region acts as a greater stimulus than pain elsewhere in the body.

MeSH Terms (14)

Adrenal Cortex Adult Analysis of Variance Case-Control Studies Circadian Rhythm Contraceptives, Oral Facial Pain Female Humans Hydrocortisone Pain Measurement Regression Analysis Sleep Temporomandibular Joint Dysfunction Syndrome

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