Publication

Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoter.

Duong DT, Waltner-Law ME, Sears R, Sealy L, Granner DK
J Biol Chem. 2002 277 (35): 32234-42

PMID: 12070172 · DOI:10.1074/jbc.M204873200

MeSH Terms (20)

Animals CCAAT-Enhancer-Binding Protein-beta Chromatin Cyclic AMP Cyclic AMP Response Element-Binding Protein Glucocorticoids Glucose Insulin Kinetics Liver Neoplasms, Experimental Luciferases Phosphoenolpyruvate Carboxykinase (GTP) Promoter Regions, Genetic Rats Recombinant Fusion Proteins RNA, Messenger RNA Polymerase II Transcription, Genetic Transfection Tumor Cells, Cultured

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