Adverse event associated with methionine loading test: a case report.

Cottington EM, LaMantia C, Stabler SP, Allen RH, Tangerman A, Wagner C, Zeisel SH, Mudd SH
Arterioscler Thromb Vasc Biol. 2002 22 (6): 1046-50

PMID: 12067919 · DOI:10.1161/01.atv.0000020400.25088.a7

The death of a control subject after an oral load of methionine for a study of the possible relationship between homocysteine and Alzheimer's disease is reported. The subject developed postload plasma concentrations of methionine far beyond those reported previously in humans given the usual oral loading dose of methionine (100 mg/kg body wt). Her preload plasma metabolite values rule out known genetic diseases that might predispose one to unusually high methionine concentrations. The most likely explanation for these events is that the subject received a substantial overdose of methionine. The possibility that extremely high methionine concentrations may lead to severe cerebral effects is discussed, and it is recommended that any move to increase the sensitivity of the usual methionine loading test by increasing the dose of methionine either not be undertaken or be taken only with extreme care.

MeSH Terms (15)

Administration, Oral African Americans Aged Brain Death Disease Susceptibility Drug Contamination Drug Overdose Fatal Outcome Female Genetic Predisposition to Disease Humans Hyperhomocysteinemia Inactivation, Metabolic Metabolism, Inborn Errors Methionine

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