ARF6: a newly appreciated player in G protein-coupled receptor desensitization.

Hunzicker-Dunn M, Gurevich VV, Casanova JE, Mukherjee S
FEBS Lett. 2002 521 (1-3): 3-8

PMID: 12067715 · DOI:10.1016/s0014-5793(02)02822-3

The luteinizing hormone/choriogonadotropin hormone receptor (LH/CG R) signals to regulate ovulation, corpus luteum formation, and fetal survival during pregnancy. Agonist binding to the LH/CG R is poorly reversible, emphasizing the importance of a cellular mechanism to temper signaling by a potentially persistently active receptor. Like other G protein-coupled receptors (GPCRs), signaling by this receptor is modulated by its binding of an arrestin. We have identified ADP ribosylation factor 6 (ARF6) as a protein whose activation state is regulated by the LH/CG R and which functions to regulate the availability of plasma membrane-docked arrestin 2 to this receptor. We hypothesize that ARF6 might also serve GPCRs other than the LH/CG R to regulate the availability of arrestin 2 for receptor desensitization.

MeSH Terms (10)

ADP-Ribosylation Factors Animals Arrestins Chorionic Gonadotropin GTP-Binding Proteins Humans Luteinizing Hormone Phosphoproteins Receptors, Cell Surface Receptors, LH

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