Lymphokine-dependent proliferation of T-lymphoid cells: regulated responsiveness and role in vivo.

Boothby M, Mora AL, Stephenson LM
Crit Rev Immunol. 2001 21 (6): 487-522

PMID: 12058862

The discovery of lymphokines stemmed from their ability to promote T-lymphocyte proliferation in vitro. Even after 20 years of intensive investigation, crucial aspects remain to be clarified about the role of specific lymphokines in T-cell proliferation and the biochemical mechanisms by which they play these roles, particularly in vivo. The present review focuses on conventional populations of TCR(alpha)beta T cells. Older findings and new insights into the function of specific lymphokines in T-lymphocyte proliferation in vivo are summarized along with unanswered questions raised by these observations. Vital contributions of lymphokines to clonal proliferation arise from two processes: the protection of cells against apoptosis and the activation of cell cycling. Findings are underscored indicating that the activity of a particular lymphokine depends on the subset of T cells (CD4 vs. CD8; naive vs. memory) to which it binds, and that point to potential pitfalls of extrapolating from tissue culture-adapted models to the regulation of T cells in vivo. After summaries of signaling mechanisms related to the proliferative activity of lymphokines, recent findings are highlighted suggesting that such signaling is a regulated and plastic process rather than one fixed schema of action.

MeSH Terms (19)

Animals Cell Division Hematopoietic Cell Growth Factors Humans Interleukin-2 Interleukin-4 Interleukin-7 Interleukin-15 Ligands Lymphocytes Lymphokines Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell, alpha-beta Receptors, Antigen, T-Cell, gamma-delta Receptors, Interleukin-2 Receptors, Interleukin-4 Receptors, Interleukin-7 Signal Transduction T-Lymphocytes

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