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The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII.

de Caestecker MP, Bottomley M, Bhattacharyya S, Payne TL, Roberts AB, Yelick PC
Biochem Biophys Res Commun. 2002 293 (5): 1556-65

PMID: 12054694 · DOI:10.1016/S0006-291X(02)00424-2

The TGF-beta superfamily consists of an array of ligands including BMP, TGF-beta, activin, and nodal subfamilies. The extensive range of biological effects elicited by TGF-beta family signaling is due in part to the large numbers and promiscuity of types I and II TGF-beta family member receptors. Alk8 is a novel type I TGF-beta family member receptor first identified in zebrafish [Dev. Dyn. 211 (4) (1998) 352], which participates in BMP signaling pathways [Development 128 (6) (2001) 849; Development 128 (6) (2001) 859; Mech. Dev. 100 (2) (2001) 275; J. Dent. Res. 80 (11) (2001) 1968]. Here we report that Alk8 also forms active signaling complexes with TGF-beta in the presence of TGF-betaRII. These results expand the signaling repertoire of zAlk8 by demonstrating an ability to participate in two distinct TGF-beta subfamily signaling pathways.

MeSH Terms (27)

Activin Receptors, Type I Amino Acid Sequence Animals Blotting, Northern Blotting, Western Bone Morphogenetic Proteins Cell Line Cross-Linking Reagents Humans In Situ Hybridization Ligands Luciferases Mice Molecular Sequence Data Mutation Precipitin Tests Protein-Serine-Threonine Kinases Protein Binding Protein Structure, Tertiary Receptor, Transforming Growth Factor-beta Type II Receptors, Transforming Growth Factor beta Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Tissue Distribution Transforming Growth Factor beta Zebrafish Zebrafish Proteins

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