Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism.

Bromberg KD, Hendricks C, Burgin AB, Osheroff N
J Biol Chem. 2002 277 (34): 31201-6

PMID: 12050172 · DOI:10.1074/jbc.M204741200

MeSH Terms (6)

Antigens, Neoplasm DNA DNA-Binding Proteins DNA Topoisomerases, Type II Humans Oligonucleotides

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