Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

Kim MJ, Bhatia-Gaur R, Banach-Petrosky WA, Desai N, Wang Y, Hayward SW, Cunha GR, Cardiff RD, Shen MM, Abate-Shen C
Cancer Res. 2002 62 (11): 2999-3004

PMID: 12036903

Recent studies of human cancers and mutant mouse models have implicated the Nkx3.1 homeobox gene as having a key role in prostate carcinogenesis. Consistent with such a role, here we show that Nkx3.1 displays growth-suppressing activities in cell culture, and that aged Nkx3.1 mutant mice display histopathological defects resembling prostatic intraepithelial neoplasia (PIN), the presumed precursor of human prostate cancer. Using a tissue recombination approach, we found that PIN-like lesions from Nkx3.1 mutants can undergo progressively severe histopathological alterations after serial transplantation in nude mice. Our findings indicate that Nkx3.1 loss-of-function is a critical event in prostate cancer initiation, and that Nkx3.1 mutant mice accurately model early stages of prostate carcinogenesis. More generally, our tissue recombination assay provides an empirical test to examine the relationship of PIN to prostate carcinoma.

MeSH Terms (18)

Animals Cell Division Disease Progression Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Gene Silencing Genetic Predisposition to Disease Homeodomain Proteins Inbreeding Male Mice Mice, Inbred C57BL Mice, Mutant Strains Mice, Nude Mutation Prostatic Intraepithelial Neoplasia Prostatic Neoplasms Transcription Factors

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