beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.

Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR
Nat Genet. 2002 31 (1): 111-5

PMID: 11923875 · DOI:10.1038/ng872

MeSH Terms (13)

Animals Glucose Intolerance Hyperinsulinism Insulin Islets of Langerhans Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Receptor, IGF Type 1 RNA, Messenger Signal Transduction

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