Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N
J Biol Chem. 2002 277 (22): 19353-7

PMID: 11923308 · DOI:10.1074/jbc.M201584200

MeSH Terms (22)

Adipose Tissue Animals Blotting, Northern CCAAT-Enhancer-Binding Proteins Crosses, Genetic DNA-Binding Proteins Fatty Liver Genotype Insulin Resistance Leptin Lipid Metabolism Lipoprotein Lipase Liver Mice Mice, Inbred C57BL Mice, Transgenic Obesity Phenotype RNA, Messenger Sterol Regulatory Element Binding Protein 1 Transcription Factors Triglycerides

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