Helicobacter pylori and gastrointestinal tract adenocarcinomas.

Peek RM, Blaser MJ
Nat Rev Cancer. 2002 2 (1): 28-37

PMID: 11902583 · DOI:10.1038/nrc703

Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

MeSH Terms (32)

Adenocarcinoma Adolescent Adult Animals Anti-Bacterial Agents Apoptosis Atrophy Bacterial Proteins Child Child, Preschool Cytokines Disease Progression Esophageal Neoplasms Female Gastric Mucosa Gastritis Gastroesophageal Reflux Gastrointestinal Neoplasms Genetic Predisposition to Disease Gerbillinae Helicobacter Infections Helicobacter pylori Humans Incidence Male Metaplasia Mice Middle Aged Polymorphism, Genetic Randomized Controlled Trials as Topic Risk Factors Stomach Neoplasms

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