Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure.

Skurnick JH, Palumbo P, DeVico A, Shacklett BL, Valentine FT, Merges M, Kamin-Lewis R, Mestecky J, Denny T, Lewis GK, Lloyd J, Praschunus R, Baker A, Nixon DF, Stranford S, Gallo R, Vermund SH, Louria DB
J Infect Dis. 2002 185 (4): 428-38

PMID: 11865394 · PMCID: PMC2743095 · DOI:10.1086/338830

Seventeen women who were persistently uninfected by human immunodeficiency virus type 1 (HIV-1), despite repeated sexual exposure, and 12 of their HIV-positive male partners were studied for antiviral correlates of non-transmission. Thirteen women had > or = 1 immune response in the form of CD8 cell noncytotoxic HIV-1 suppressive activity, proliferative CD4 cell response to HIV antigens, CD8 cell production of macrophage inflammatory protein-1 beta, or ELISPOT assay for HIV-1-specific interferon-gamma secretion. The male HIV-positive partners without AIDS had extremely high CD8 cell counts. All 8 male partners evaluated showed CD8 cell-related cytotoxic HIV suppressive activity. Reduced CD4 cell susceptibility to infection, neutralizing antibody, single-cell cytokine production, and local antibody in the women played no apparent protective role. These observations suggest that the primary protective factor is CD8 cell activity in both the HIV-positive donor and the HIV-negative partner. These findings have substantial implications for vaccine development.

MeSH Terms (17)

Acquired Immunodeficiency Syndrome Adult CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Chemokines Female HIV-1 HIV Antibodies Humans Interferon-gamma Lymphocyte Activation Male Middle Aged Sexual Behavior T-Lymphocytes, Cytotoxic Viral Load Virus Replication

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