The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis.

Burgess S, Reim G, Chen W, Hopkins N, Brand M
Development. 2002 129 (4): 905-16

PMID: 11861474 · DOI:10.1242/dev.129.4.905

MeSH Terms (18)

Alleles Animals DNA-Binding Proteins Early Growth Response Protein 2 Female Gastrula Gene Expression Male Mammals Mesencephalon Morphogenesis Mutagenesis Octamer Transcription Factor-3 PAX2 Transcription Factor Rhombencephalon Transcription Factors Zebrafish Zebrafish Proteins

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