PRL-releasing peptide interacts with leptin to reduce food intake and body weight.

Ellacott KL, Lawrence CB, Rothwell NJ, Luckman SM
Endocrinology. 2002 143 (2): 368-74

PMID: 11796488 · DOI:10.1210/endo.143.2.8608

PRL-releasing peptide (PrRP) is a novel anorexigen that reduces food intake and body weight gain in rats. In common with other anorexigens, PrRP mRNA expression is reduced during states of negative energy balance, i.e. lactation and fasting in female rats. In this study, we examined the interaction between PrRP and the adiposity signal, leptin, which interacts with a number of peptidergic systems in the brain to regulate energy homeostasis. Intracerebroventricular coadministration of 4 nmol PrRP and 1 microg leptin in rats resulted in additive reductions in nocturnal food intake and body weight gain and an increase in core body temperature compared with each peptide alone. We show also, by quantitative in situ hybridization, that PrRP mRNA is reduced in fasted male rats and obese Zucker rats, indicating that PrRP mRNA expression, like that of other anorexigens, may be regulated by leptin. Finally we show, using immunohistochemistry, that greater than 90% of PrRP neurons in all regions where PrRP is expressed contain leptin receptors. Thus, we provide evidence for PrRP neurons forming part of the leptin-sensitive brain circuitry involved in the regulation of food intake and energy homeostasis.

MeSH Terms (25)

Animals Body Temperature Body Weight Depression, Chemical Dorsomedial Hypothalamic Nucleus Drug Interactions Eating Energy Metabolism Fluorescent Antibody Technique, Indirect Hypothalamic Hormones Immunohistochemistry Injections, Intraventricular In Situ Hybridization Leptin Male Neuropeptides Obesity Prolactin Prolactin-Releasing Hormone Rats Rats, Sprague-Dawley Rats, Zucker Solitary Nucleus Tyrosine 3-Monooxygenase Ventromedial Hypothalamic Nucleus

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